Fisogatinib | BLU-554 | 1707289-21-1

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	￥316.00	Visible after login	- +
5 mg	3-5 days	￥866.00	Visible after login	- +
10 mg	3-5 days	￥1388.00	Visible after login	- +
25 mg	3-5 days	￥2266.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5 days

￥316.00

Visible after login

- +

5 mg

3-5 days

￥866.00

Visible after login

- +

10 mg

3-5 days

￥1388.00

Visible after login

- +

25 mg

3-5 days

￥2266.00

Visible after login

- +

Product Overview

Product Name	Fisogatinib (Synonyms: BLU-554)
CAS	1707289-21-1
Formula	C24H24Cl2N4O4
MW	503.38
MDL	MFCD30496704
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

Fisogatinib (BLU-554) is a potent and highly selective oral FGFR4 inhibitor with an IC50 of 5 nM, demonstrating significant anti-tumor activity in HCC models reliant on FGFR4 signaling.Its IC50 values for FGFR1-3 are in the range of 624-2203 nM, highlighting its selectivity over other FGFR isoforms.

Related literature

Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

PMID: 30802754 DOI: 10.1016/j.jchromb.2019.02.017

FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer

PMID: 31409633 DOI: 10.1158/1535-7163.MCT-18-1291

First-in-human study of BLU-554, a potent, highly selective FGFR4 inhibitor designed for hepatocellular carcinoma (HCC) with FGFR4 pathway activation. EJC.

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History

CL3126

Fisogatinib (Synonyms: BLU-554)

1707289-21-1 98+%

N-((3S,4S)-3-((6-(2,6-二氯-3,5-二甲氧基苯基)喹唑啉-2-基)氨基)四氢-2H-吡喃-4-基)丙烯酰胺

Chemical safety data sheet(MSDS)