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Product Overview

Product Name	Dihexa (Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2)
CAS	1401708-83-5
Formula	C27H44N4O5
MW	504.66
MDL	MFCD30533409
Appearance	White to gray white powder
Storage condition	Store at 0-4°C for short-term or -20°C for long-term in a dry, dark environment.

Product details

Dihexa, an angiotensin IV analog, is a potent cognitive enhancer that crosses the BBB and binds to HGF with high affinity (Kd=65 pM), activating c-Met receptor pathways. It shows significant antidementia effects in animal models, suggesting therapeutic potential for Alzheimer's disease treatment.

Related literature

The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.

PMID: 25187433 PMCID: PMC4201273 DOI: 10.1124/jpet.114.218735

Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.

PMID: 23055539 PMCID: PMC3533412 DOI: 10.1124/jpet.112.199497

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History

CL2930A

Raloxifene | Keoxifene | LY156758 free base | LY139481

84449-90-1 98+%

CLP1144

Dihexa (Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2)

1401708-83-5 98+%

N-((S)-1-(((2S,3S)-1-((6-氨基-6-氧代己基)氨基)-3-甲基-1-氧代戊烷-2-基)氨基)-3-(4-羟基苯基)-1-氧代丙烷-2-基)己酰胺 ;益智二肽

Chemical safety data sheet(MSDS)