RepSox|E-616452|E616452|E 616452|SJN 2511|SJN-2511|SJN2511

规格	库存	目录价	会员专享价	数量
5 mg	In-stock	￥488.00	登录后可见	- +
10 mg	In-stock	￥748.00	登录后可见	- +
25 mg	In-stock	￥1436.00	登录后可见	- +
50 mg	In-stock	￥2136.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

5 mg

In-stock

￥488.00

登录后可见

- +

10 mg

In-stock

￥748.00

登录后可见

- +

25 mg

In-stock

￥1436.00

登录后可见

- +

50 mg

In-stock

￥2136.00

登录后可见

- +

基本信息

英文名称	RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
中文名称	2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)
CAS号	446859-33-2
分子式	C17H13N5
分子量	287.32
MDL	MFCD09037561
外观	Light brown to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.
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2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)

RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)

化学品安全说明书(MSDS)

质检证书(COA)