首页 > 产品目录 > 信号通路 > Microbiology/Virology/Anti-infection > HIV Protease > N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺；替拉那韦

N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺；替拉那韦

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Tipranavir | TPV | PNU-140690

产品编号：CL1030 CAS No.：174484-41-4 MDLNo：MFCD00949098 分子式：C31H33F3N2O5S 分子量：602.66

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规格	库存	目录价	会员专享价	数量
1 mg	3-5days	￥868.00	登录后可见	- +
5 mg	3-5days	￥2536.00	登录后可见	- +

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基本信息
相关文档
产品详情
相关文献

基本信息

英文名称	Tipranavir \| TPV \| PNU-140690
中文名称	N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺；替拉那韦
CAS号	174484-41-4
分子式	C31H33F3N2O5S
分子量	602.66
MDL	MFCD00949098
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CL^pro activity.

相关文献

Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice.

PMID: 20103582 PMCID: PMC2872945 DOI: 10.1124/dmd.109.030817

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Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol.

PMID: 23015723 PMCID: PMC3503118 DOI: 10.1128/JVI.07234-11

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Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther.

PMID: 34052830 PMCID: PMC8164054 DOI: 10.1038/s41392-021-00628-x

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