英文名称 | Ozanimod | RPC-1063 |
---|---|
中文名称 | 奥扎莫德 |
CAS号 | 1306760-87-1 |
分子式 | C23H24N4O3 |
分子量 | 404.46 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Ozanimod | RPC-1063 |
---|---|
中文名称 | 奥扎莫德 |
CAS号 | 1306760-87-1 |
分子式 | C23H24N4O3 |
分子量 | 404.46 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS).
PMID: 34535564 DOI: 10.1124/jpet.121.000741
PMID: 26990079 PMCID: PMC4867749 DOI: 10.1111/bph.13476