| 英文名称 | RO 61-8048 |
|---|---|
| 中文名称 | Ro 61-8048 |
| CAS号 | 199666-03-0 |
| 分子式 | C17H15N3O6S2 |
| 分子量 | 421.45 |
| 外观 | Light yellow to yellow powder |
| 储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
| 英文名称 | RO 61-8048 |
|---|---|
| 中文名称 | Ro 61-8048 |
| CAS号 | 199666-03-0 |
| 分子式 | C17H15N3O6S2 |
| 分子量 | 421.45 |
| 外观 | Light yellow to yellow powder |
| 储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Ro61-8048 is a potent Kynurenine hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM). Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia. Ro 61-8048 may be potentially useful for the treatment of dyskinesias. Ro 61-8048 could be a new avenue to reduce neuronal loss in brain ischemia.
PMID: 9435907 DOI: 10.1021/jm970467t
https://doi.org/10.1016/S0028-3908(99)00048-9
PMID: 18353306 DOI: 10.1016/j.ejphar.2008.02.052