| 英文名称 | Monomethyl auristatin E (Synonyms: MMAE; SGD-1010;Monomethylauristatin E) |
|---|---|
| 中文名称 | 一甲基澳瑞他汀 E |
| CAS号 | 474645-27-7 |
| 分子式 | C39H67N5O7 |
| 分子量 | 717.98 |
| 英文名称 | Monomethyl auristatin E (Synonyms: MMAE; SGD-1010;Monomethylauristatin E) |
|---|---|
| 中文名称 | 一甲基澳瑞他汀 E |
| CAS号 | 474645-27-7 |
| 分子式 | C39H67N5O7 |
| 分子量 | 717.98 |
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.