首页 > 产品目录 > 信号通路 > PI3K/Akt/mTOR > mTOR > (1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-10,21-二甲氧基-6,8,12,14,20,26-六甲基-1,5,11,28,29-五氧代-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-二十四氢-3H-23,27-环氧吡啶并[2,1-c][1]氮杂环三十一烷-3-基)丙基)-2-甲氧基环己基二甲基亚膦酸酯

(1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-10,21-二甲氧基-6,8,12,14,20,26-六甲基-1,5,11,28,29-五氧代-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-二十四氢-3H-23,27-环氧吡啶并[2,1-c][1]氮杂环三十一烷-3-基)丙基)-2-甲氧基环己基二甲基亚膦酸酯

Ridaforolimus (Synonyms: MK-8669; Deforolimus; AP23573; 42-(二甲基亚膦酰)雷帕霉素)

产品编号：CL1761 CAS No.：572924-54-0 MDLNo：MFCD13184816 分子式：C53 H84 N O14 P 分子量：990.21

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基本信息

英文名称	Ridaforolimus (Synonyms: MK-8669; Deforolimus; AP23573; 42-(二甲基亚膦酰)雷帕霉素)
中文名称	(1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-10,21-二甲氧基-6,8,12,14,20,26-六甲基-1,5,11,28,29-五氧代-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-二十四氢-3H-23,27-环氧吡啶并[2,1-c][1]氮杂环三十一烷-3-基)丙基)-2-甲氧基环己基二甲基亚膦酸酯
CAS号	572924-54-0
分子式	C53 H84 N O14 P
分子量	990.21
MDL	MFCD13184816
外观	White to light yellow powder

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Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC₅₀ of 0.2 nM in HT-1080 cells.

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Deforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens.

PMID: 21482695 DOI: 10.1158/1535-7163.MCT-10-0792

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.

PMID: 29275959 DOI: 10.1016/j.cmet.2017.11.006

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(1R,2R,4S)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-10,21-二甲氧基-6,8,12,14,20,26-六甲基-1,5,11,28,29-五氧代-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-二十四氢-3H-23,27-环氧吡啶并[2,1-c][1]氮杂环三十一烷-3-基)丙基)-2-甲氧基环己基二甲基亚膦酸酯

572924-54-0 98+%