| 英文名称 | LY2109761 |
|---|---|
| 中文名称 | LY2109761 |
| CAS号 | 700874-71-1 |
| 分子式 | C26H27N5O2 |
| 分子量 | 441.52 |
| 外观 | White to yellow powder |
| 储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
| 英文名称 | LY2109761 |
|---|---|
| 中文名称 | LY2109761 |
| CAS号 | 700874-71-1 |
| 分子式 | C26H27N5O2 |
| 分子量 | 441.52 |
| 外观 | White to yellow powder |
| 储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.
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