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司他生坦钠 | 西他塞坦钠

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Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)

产品编号：CL2102 CAS No.：210421-74-2 MDLNo： 分子式：C18H14ClN2NaO6S2 分子量：476.89

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基本信息

英文名称	Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)
中文名称	司他生坦钠 \| 西他塞坦钠
CAS号	210421-74-2
分子式	C18H14ClN2NaO6S2
分子量	476.89
外观	Light yellow to yellow powder
储存条件	4°C, sealed storage, away from moisture

产品详情

Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH.

相关文献

Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.

PMID: 20628435 DOI: 10.1139/Y10-060

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Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.

PMID: 10799286 DOI: 10.1006/pupt.2000.0237

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Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.

PMID: 20693396 DOI: 10.1152/ajpheart.00418.2010

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