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地瑞那韦/达芦那韦

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Darunavir (TMC114)

产品编号：CL2205 CAS No.：206361-99-1 MDLNo： 分子式：C₂₇H₃₇N₃O₇S 分子量：547.66

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规格	库存	目录价	会员专享价	数量
200 mg	In-stock	￥300.00	登录后可见	- +
500 mg	In-stock	￥450.00	登录后可见	- +
1 g	In-stock	￥750.00	登录后可见	- +
5 g	In-stock	￥3000.00	登录后可见	- +

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基本信息

英文名称	Darunavir (TMC114)
中文名称	地瑞那韦/达芦那韦
CAS号	206361-99-1
分子式	C₂₇H₃₇N₃O₇S
分子量	547.66
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Darunavir is a drug used to treat HIV infection. It is in the protease inhibitor class. Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC50 of 0.003 μmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents.