英文名称 | Olaparib (Synonyms: AZD2281; KU0059436; Ku-0059436) |
---|---|
中文名称 | 奥拉帕尼 |
CAS号 | 763113-22-0 |
分子式 | C₂₄H₂₃FN₄O₃ |
分子量 | 434.46 |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Olaparib (Synonyms: AZD2281; KU0059436; Ku-0059436) |
---|---|
中文名称 | 奥拉帕尼 |
CAS号 | 763113-22-0 |
分子式 | C₂₄H₂₃FN₄O₃ |
分子量 | 434.46 |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
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