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奥巴克拉甲磺酸盐

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Obatoclax mesylate (GX15-070)

产品编号:CL2345 CAS No.:803712-79-0 MDLNo: 分子式:C20H19N3O.CH4O3S 分子量:413.49
规格 库存 目录价 会员专享价 数量
5 mg In-stock ¥660.00 登录后可见
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10 mg In-stock ¥1066.00 登录后可见
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基本信息
英文名称 Obatoclax mesylate (GX15-070)
中文名称奥巴克拉甲磺酸盐
CAS号803712-79-0
分子式C20H19N3O.CH4O3S
分子量413.49
外观 Purple to black powder
产品详情

Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

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