| 英文名称 | Midostaurin (Synonyms: PKC412; CGP 41251) |
|---|---|
| 中文名称 | 米哚妥林 |
| CAS号 | 120685-11-2 |
| 分子式 | C35H30N4O4 |
| 分子量 | 570.64 |
| 外观 | White to yellow powder |
| 储存条件 | -20°C, sealed storage, away from moisture |
| 英文名称 | Midostaurin (Synonyms: PKC412; CGP 41251) |
|---|---|
| 中文名称 | 米哚妥林 |
| CAS号 | 120685-11-2 |
| 分子式 | C35H30N4O4 |
| 分子量 | 570.64 |
| 外观 | White to yellow powder |
| 储存条件 | -20°C, sealed storage, away from moisture |
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
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