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奥拉替尼马来酸盐 | 奥克拉西替尼 (1208319-27-0)

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Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)

产品编号:CL2531 CAS No.:1640292-55-2 MDLNo: 分子式:C19H27N5O6S 分子量:453.51
规格 库存 目录价 会员专享价 数量
5 mg 3-5days ¥650.00 登录后可见
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10 mg 3-5days ¥975.00 登录后可见
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25 mg 3-5days ¥1800.00 登录后可见
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基本信息
英文名称 Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)
中文名称奥拉替尼马来酸盐 | 奥克拉西替尼 (1208319-27-0)
CAS号1640292-55-2
分子式C19H27N5O6S
分子量453.51
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
产品详情

Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.
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