Necrosulfonamide; (E)-Necrosulfonamide

规格	库存	目录价	会员专享价	数量
5 mg	3-5days	￥550.00	登录后可见	- +
10 mg	3-5days	￥880.00	登录后可见	- +
25 mg	3-5days	￥1380.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

5 mg

3-5days

￥550.00

登录后可见

- +

10 mg

3-5days

￥880.00

登录后可见

- +

25 mg

3-5days

￥1380.00

登录后可见

- +

基本信息

英文名称	Necrosulfonamide; (E)-Necrosulfonamide
中文名称	Necrosulfonamide
CAS号	1360614-48-7
分子式	C18H15N5O6S2
分子量	461.47
外观	Light yellow to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Necrosulfonamide is a potent and highly specific and potent necrosis inhibitor which blocks mixed lineage kinase domain-like protein (MLKL). Through blocking the activity of MLKL's N-terminal CC domain, necrosulfonamide prevents MLKL-mediated necrosis. It prevents necrosis from occurring after RIP3 activation. Even at a 5 μM concentration, necrosulfonamide has no impact on the apoptosis that TNF-α plus Smac mimetic induces in Panc-1 cells that do not express RIP3. The programmed necrosis (necroptosis) pathway uses the receptor-interacting serine-threonine kinase 3 (RIP3) as a key signaling molecule. This pathway is crucial for the development, tissue damage response, and antiviral immunity of many physiological and pathological conditions.

Necrosulfonamide

Necrosulfonamide; (E)-Necrosulfonamide

化学品安全说明书(MSDS)