A-484954 | 142557-61-7 | eEF2K Inhibitor

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库存

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会员专享价

数量

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基本信息

英文名称	A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
中文名称	7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺
CAS号	142557-61-7
分子式	C13H15N5O3
分子量	289.29
MDL	MFCD22683836

产品详情

A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.
A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
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7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺

A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide

化学品安全说明书(MSDS)