英文名称 | Rosiglitazone maleate | BRL 49653C |
---|---|
中文名称 | 马来酸罗格列酮 |
CAS号 | 155141-29-0 |
分子式 | C18H19N3O3S·C4H4O4 |
分子量 | 473.50 | 357.43(free) |
外观 | White to off-white powder |
储存条件 | 4°C, sealed storage, away from moisture |
英文名称 | Rosiglitazone maleate | BRL 49653C |
---|---|
中文名称 | 马来酸罗格列酮 |
CAS号 | 155141-29-0 |
分子式 | C18H19N3O3S·C4H4O4 |
分子量 | 473.50 | 357.43(free) |
外观 | White to off-white powder |
储存条件 | 4°C, sealed storage, away from moisture |
Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).