| 英文名称 | Darbufelone mesilate | CI-1004 mesylate |
|---|---|
| 中文名称 | 甲磺酸达布非龙 |
| CAS号 | 139340-56-0 |
| 分子式 | C18H24N2O2S·CH4O3S |
| 分子量 | 428.57 | 332.46 (free) |
| 外观 | White to light yellow powder |
| 储存条件 | 4°C, sealed storage, away from moisture and light |
| 英文名称 | Darbufelone mesilate | CI-1004 mesylate |
|---|---|
| 中文名称 | 甲磺酸达布非龙 |
| CAS号 | 139340-56-0 |
| 分子式 | C18H24N2O2S·CH4O3S |
| 分子量 | 428.57 | 332.46 (free) |
| 外观 | White to light yellow powder |
| 储存条件 | 4°C, sealed storage, away from moisture and light |
Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).