BAN ORL 24 | 1401463-54-4

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规格

库存

目录价

会员专享价

数量

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基本信息

英文名称	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
中文名称	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
CAS号	1401463-54-4
分子式	C27H35N3O2·2HCl
分子量	506.51 \| 433.60 (free)
外观	White to off-white powder
储存条件	-20°C, protect from light, stored under nitrogen

产品详情

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (K_i = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (K_is = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA₂ = 9.98) and calcium mobilization (K_B = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.

BAN ORL 24 2HCl | BAN-ORL-24 2HCl

BAN ORL 24 2HCl | BAN-ORL-24 2HCl

化学品安全说明书(MSDS)