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Humax-Il15

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Humax-Il15

产品编号:CLA1144 CAS No.:N/A MDLNo: 分子式: 分子量:
规格 库存 目录价 会员专享价 数量
0.1 mg 3-5days ¥9000.00 登录后可见
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1 mg 3-5days ¥13000.00 登录后可见
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5 mg 3-5days ¥22000.00 登录后可见
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基本信息
英文名称 Humax-Il15
中文名称Humax-Il15
CAS号N/A
储存条件 Store at 2 to 8 °C for 1-2 weeks. Store at -20 °C for 12 months. Store at -80 °C for long term storage. Use a manual defrost freezer and avoid repeated freeze-thaw cycles, away from light.
产品详情

HuMax-IL15 is a high affinity fully humanized IgG1 anti-IL-15 monoclonal antibody designed to neutralize IL-15 by binding receptor-bound IL-15 at the site where it interacts with the common γ-chain. This thereby interferes with its signaling, putatively involving the recruitment and activation of T cells, maintenance of T cell memory, activation of neutrophils, and immortalization of fibroblast-like synoviocytes and endothelial cells. IL-15 also appears to play a significant role in natural killer cell ontogeny and effector function, at least in mice. IL-15 appear to be expressed on macrophages, endothelial cells, and fibroblast-like synoviocytes in rheumatoid arthritis synovial tissues, and this is, in part, the basis from which a Phase I/II study was conducted . HuMax-IL15 appears tolerable with a favorable side effect profile and even an encouraging efficacy profile in terms of improvement of symptom scores.

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