英文名称 | Hyperforin |
---|---|
中文名称 | 贯叶金丝桃素 |
CAS号 | 11079-53-1 |
分子式 | C35H52O4 |
分子量 | 536.785 |
外观 | Light yellow to light yellow waxy solid |
储存条件 | Fill with nitrogen or dissolve in polar solvents and store in a low temperature environment below -30 ℃ away from light. |
英文名称 | Hyperforin |
---|---|
中文名称 | 贯叶金丝桃素 |
CAS号 | 11079-53-1 |
分子式 | C35H52O4 |
分子量 | 536.785 |
外观 | Light yellow to light yellow waxy solid |
储存条件 | Fill with nitrogen or dissolve in polar solvents and store in a low temperature environment below -30 ℃ away from light. |
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
PMID: 23875811 DOI: 10.1111/jnc.12376
Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice.
PMID: 30618608 PMCID: PMC6299069 DOI: 10.3389/fnmol.2018.00456
Biosynthesis of hyperforin in Hypericum perforatum.
PMID: 12361406 DOI: 10.1021/jm0209782
PMID: 34025642 PMCID: PMC8131513 DOI: 10.3389/fimmu.2021.635076