英文名称 | Homoharringtonine (HHT) | Omacetaxine mepesuccinate |
---|---|
中文名称 | 高三尖杉酯碱 |
CAS号 | 26833-87-4 |
分子式 | C29H39NO9 |
分子量 | 545.62 |
MDL | MFCD05618221 |
外观 | Off-white to yellow powder |
储存条件 | 4°C, protect from light |
英文名称 | Homoharringtonine (HHT) | Omacetaxine mepesuccinate |
---|---|
中文名称 | 高三尖杉酯碱 |
CAS号 | 26833-87-4 |
分子式 | C29H39NO9 |
分子量 | 545.62 |
MDL | MFCD05618221 |
外观 | Off-white to yellow powder |
储存条件 | 4°C, protect from light |
Homoharringtonine (Omacetaxine mepesuccinate; HHT) is a cytotoxic alkaloid derived from the Cephalotaxus tree, known for its significant antitumor properties. HHT acts primarily by inhibiting translation elongation, which disrupts protein synthesis crucial for cancer cell survival. This mechanism leads to the rapid degradation of several short-lived proteins, including Mcl-1 and c-Myc, triggering apoptosis in various cancer types, particularly in hematological malignancies such as acute myeloid leukemia (AML).
PMID: 26166037 PMCID: PMC4499885 DOI: 10.1038/srep08477