Home > Category > Signaling Pathways > Stem Cells & Wnt > GSK-3 > Laduviglusib dihydrochloride | CHIR-99021 dihydrochloride | CT99021 dihydrochloride

拉格鲁西布二盐酸盐 | CHIR-99021二盐酸盐 |

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Catalog No：CL1006C CAS No.：2109414-84-6 MDLNo： Formula：C22H18Cl2N8·2HCl MW：538.26

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Product Overview

Product Name	Laduviglusib dihydrochloride \| CHIR-99021 dihydrochloride \| CT99021 dihydrochloride
CAS	2109414-84-6
Formula	C22H18Cl2N8·2HCl
MW	538.26

Product details

Laduviglusib (CHIR-99021) dihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.

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