Home > Category > Signaling Pathways > DNA Damage/DNA Repair > Nucleoside Antimetabolite/Analog > Clofarabine (Synonyms: Clofarex;Evoltra;Clolar)

氯法拉滨 | 克罗拉滨

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Catalog No：CL2574 CAS No.：123318-82-1 MDLNo：MFCD00871077 Formula：C10H11ClFN5O3 MW：303.68

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Product Overview

Product Name	Clofarabine (Synonyms: Clofarex;Evoltra;Clolar)
CAS	123318-82-1
Formula	C10H11ClFN5O3
MW	303.68
MDL	MFCD00871077
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC₅₀=65 nM) by binding to the allosteric site on the regulatory subunit.

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Related literature

[Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells]

PMID: 22739157

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Discovery and development of clofarabine: a nucleoside analogue for treating cancer.

PMID: 17016426 DOI: 10.1038/nrd2055

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Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics.

PMID: 27316580 DOI: 10.1016/j.kjms.2016.04.001

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