Tolcapone | Ro 40-7592

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Tolcapone \| Ro 40-7592
CAS	134308-13-7
Formula	C14H11NO5
MW	273.24
Appearance	Light yellow to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

Related literature

Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone.

PMID: 9681662 DOI: 10.1007/s002280050448

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.

PMID: 20150427 PMCID: PMC2865316 DOI: 10.1074/jbc.M109.080390

Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma

PMID: 28429453 PMCID: PMC5463066 DOI: 10.1002/cam4.1065

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