PIK-90 | 677338-12-4

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	PIK-90
CAS	677338-12-4
Formula	C18H17N5O3
MW	351.36
MDL	MFCD12910483
Appearance	Off-white to yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

PIK-90 is recognized as a potent inhibitor of both DNA-PK and PI3K, demonstrating its inhibitory effects on the p110α, p110γ, and DNA-PK with respective IC50 values of 11, 18, and 13 nM. This compound plays a significant role in the realm of molecular biology and cancer research, where its ability to target these key enzymes is of paramount importance.

Related literature

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

PMID: 16647110 PMCID: PMC2946820 DOI: 10.1016/j.cell.2006.03.035

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.

PMID: 19318683 PMCID: PMC4580965 DOI: 10.1182/blood-2008-06-165068

Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.

PMID: 22802621 PMCID: PMC3411950 DOI: 10.1073/pnas.1202492109

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