Pelitinib (Synonyms: EKB-569; WAY-EKB 569); CAS: 257933-82-7

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Product Overview

Product Name	Pelitinib (Synonyms: EKB-569; WAY-EKB 569)
CAS	257933-82-7
Formula	C24H23ClFN5O2
MW	467.92
MDL	MFCD09837868
Appearance	White to off-white powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

Pelitinib (EKB-569) is a potent, irreversible EGFR inhibitor with an IC50 of 38.5 nM, displaying selectivity over Src, MEK/ERK, and ErbB2 with respective IC50s of 282 nM, 800 nM, and 1255 nM.

Related literature

Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes.

PMID: 14749472

Combinatorial chemoprevention of intestinal neoplasia.

PMID: 10973323 DOI: 10.1038/79534

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