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阿贝西利甲磺酸盐

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Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate

产品编号：CL1153 CAS No.：1231930-82-7 MDLNo： 分子式：C28H36F2N8O3S 分子量：602.70

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规格	库存	目录价	会员专享价	数量
5 mg	3-5days	￥566.00	登录后可见	- +
10 mg	3-5days	￥1066.00	登录后可见	- +

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基本信息

英文名称	Abemaciclib Mesylate \| LY2835219 Mesylate) \| Abemaciclib Methanesulfonate
中文名称	阿贝西利甲磺酸盐
CAS号	1231930-82-7
分子式	C28H36F2N8O3S
分子量	602.70
外观	White to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

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