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MMAF sodium (Monomethylauristatin F sodium)

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MMAF sodium (Monomethylauristatin F sodium)

产品编号:CL1348B CAS No.:1799706-65-2 MDLNo: 分子式:C39H64N5NaO8 分子量:753.94
规格 库存 目录价 会员专享价 数量
5 mg 3-5days ¥600.00 登录后可见
- +
10 mg 3-5days ¥1000.00 登录后可见
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25 mg 3-5days ¥1800.00 登录后可见
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基本信息
英文名称 MMAF sodium (Monomethylauristatin F sodium)
中文名称MMAF sodium (Monomethylauristatin F sodium)
CAS号1799706-65-2
分子式C39H64N5NaO8
分子量753.94
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
产品详情

Monomethyl auristatin F (MMAF) sodium is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. MMAF plus its attachment structure to the antibody are referred to as mafodotin in the International Nonproprietary Names for MMAF-antibody-conjugates. Since the N-terminal amino group of MMAF only has one methyl substituent rather than two, as it does in auristatin F itself, it is actually desmethyl-auristatin F.

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