| 英文名称 | Niraparib (MK-4827) |
|---|---|
| 中文名称 | 尼拉帕尼 |
| CAS号 | 1038915-60-4 |
| 分子式 | C₁₉H₂₀N₄O |
| 分子量 | 320.39 |
| 外观 | White to light yellow powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
| 英文名称 | Niraparib (MK-4827) |
|---|---|
| 中文名称 | 尼拉帕尼 |
| CAS号 | 1038915-60-4 |
| 分子式 | C₁₉H₂₀N₄O |
| 分子量 | 320.39 |
| 外观 | White to light yellow powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.