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布立尼布

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Brivanib (Synonyms: BMS-540215)

产品编号：CL2355 CAS No.：649735-46-6 MDLNo： 分子式：C19H19FN4O3 分子量：370.38

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规格	库存	目录价	会员专享价	数量
5 mg	3-5days	￥636.00	登录后可见	- +
10 mg	3-5days	￥1068.00	登录后可见	- +

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基本信息

英文名称	Brivanib (Synonyms: BMS-540215)
中文名称	布立尼布
CAS号	649735-46-6
分子式	C19H19FN4O3
分子量	370.38
外观	White to light brown powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β.
Tags: buy Brivanib | purchase Brivanib | Brivanib cost | order Brivanib | Brivanib chemical structure | Brivanib in vivo | Brivanib in vitro | Brivanib formula | Brivanib molecular weight

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Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

PMID: 16570908 DOI: 10.1021/jm051106d

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Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling.

PMID: 26528545 PMCID: PMC4631495 DOI: 10.1371/journal.pone.0142355

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Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma.

PMID: 18829493 DOI: 10.1158/1078-0432.CCR-08-0509

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