CX-5461

规格	库存	目录价	会员专享价	数量
2 mg	3-5days	￥288.00	登录后可见	- +
5 mg	3-5days	￥498.00	登录后可见	- +
10 mg	3-5days	￥898.00	登录后可见	- +
25 mg	3-5days	￥1616.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

2 mg

3-5days

￥288.00

登录后可见

- +

5 mg

3-5days

￥498.00

登录后可见

- +

10 mg

3-5days

￥898.00

登录后可见

- +

25 mg

3-5days

￥1616.00

登录后可见

- +

基本信息

英文名称	CX-5461 \| Pidnarulex
中文名称	CX-5461
CAS号	1138549-36-6
分子式	C27H27N7O2S
分子量	513.61
外观	White to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.

CX-5461 | Pidnarulex

化学品安全说明书(MSDS)