Divarasib | GDC-6036 | RG6330

规格	库存	目录价	会员专享价	数量
1 mg	3-5 days	￥1866.00	登录后可见	- +
2 mg	3-5 days	￥2886.00	登录后可见	- +
5 mg	3-5 days	￥4688.00	登录后可见	- +
10 mg	3-5 days	￥7506.00	登录后可见	- +

规格

库存

目录价

会员专享价

数量

1 mg

3-5 days

￥1866.00

登录后可见

- +

2 mg

3-5 days

￥2886.00

登录后可见

- +

5 mg

3-5 days

￥4688.00

登录后可见

- +

10 mg

3-5 days

￥7506.00

登录后可见

- +

基本信息

英文名称	Divarasib (Synonyms: GDC-6036; RG6330)
中文名称	1-((S)-4-(7-((R)-6-氨基-4-甲基-3-(三氟甲基)吡啶-2-基)-6-氯-8-氟-2-(((S)-1-甲基吡咯烷-2-基)甲氧基)喹唑啉-4-基)-3-甲基哌嗪-1-基)丙-2-烯-1-酮
CAS号	2417987-45-0
分子式	C29H32ClF4N7O2
分子量	622.06
外观	White to light yellow powder
储存条件	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

产品详情

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective inhibitor of the KRAS G12C mutation, boasting an IC50 of less than 0.01 μM. This investigational drug covalently binds to the switch II (SW-II) pocket of the KRAS G12C protein, effectively trapping it in an inactive GDP-bound state. By irreversibly locking the KRAS G12C oncoprotein in this inactive configuration, Divarasib inhibits tumor cell proliferation. It is currently under investigation for its potential use in treating solid tumors, including non-small cell lung cancer (NSCLC), colorectal cancer, and other malignancies.

1-((S)-4-(7-((R)-6-氨基-4-甲基-3-(三氟甲基)吡啶-2-基)-6-氯-8-氟-2-(((S)-1-甲基吡咯烷-2-基)甲氧基)喹唑啉-4-基)-3-甲基哌嗪-1-基)丙-2-烯-1-酮

Divarasib (Synonyms: GDC-6036; RG6330)

化学品安全说明书(MSDS)