Home > Category > Signaling Pathways > Stem Cells & Wnt > ROCK > Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride)

trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐 | Y-27632 二盐酸盐 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)环己烷甲酰胺 二盐酸盐

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Catalog No:CL1003 CAS No.:129830-38-2 MDLNo:MFCD03490488 Formula:C14H21N3O.2HCl MW:320.26 | 247.34(free)
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5 mg In-stock ¥650.00 Visible after login
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10 mg In-stock ¥900.00 Visible after login
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25 mg In-stock ¥1600.00 Visible after login
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50 mg In-stock ¥2636.00 Visible after login
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Product Overview
Product Name Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride)
CAS129830-38-2
FormulaC14H21N3O.2HCl
MW320.26 | 247.34(free)
MDLMFCD03490488
AppearanceWhite to off-white powder
Storage condition4°C, sealed storage, away from moisture
Product details

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. 
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