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Product Overview

Product Name	Amifostine
CAS	20537-88-6
Formula	C5H15N2O3PS
MW	214.22
MDL	MFCD00233058
Appearance	White to off-white powder
Storage condition	Powder -20°C3 years ; 4°C 2 years ;\| In solvent -80°C 6 months ; -20°C 1 month

Product details

Amifostine (WR2721) is a potent cytoprotective and radioprotective agent, selectively safeguarding normal tissues from chemotherapy and radiation-induced damage. It acts as a prodrug, activating to WR-1065 by alkaline phosphatase, which scavenges free radicals and protects cells. Amifostine also induces HIF-α1 and p53, key regulators in the cellular response to hypoxia and DNA damage. Its antiangiogenic properties, by modulating VEGF-A, suggest potential in inhibiting tumor vasculature. Recent studies highlight its renal toxicity reduction and explore PEGylation to enhance safety and efficacy, making Amifostine a versatile protector in cancer therapies.

Related literature

Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress.

PMID: 28392886 PMCID: PMC5368387 DOI: 10.1155/2017/4130824

Amifostine: the first selective-target and broad-spectrum radioprotector.

PMID: 17602063 DOI: 10.1634/theoncologist.12-6-738

Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha.

PMID: 14574457 DOI: 10.1007/s00280-003-0691-z

CL1024A

Amifostine Trihydrate | WR2721 trihydrate

History

氨磷汀

Chemical safety data sheet(MSDS)