Home > Category > Signaling Pathways > Cell Cycle > Aurora Kinase > Tozasertib(VX-680;MK-0457)

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Catalog No：CL2144 CAS No.：639089-54-6 MDLNo： Formula：C23H28N8OS MW：464.59

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
25 mg	In-stock	￥350.00	Visible after login	- +
50 mg	In-stock	￥550.00	Visible after login	- +
100 mg	In-stock	￥860.00	Visible after login	- +
500 mg	In-stock	￥2800.00	Visible after login	- +

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Product Overview

Product Name	Tozasertib(VX-680;MK-0457)
CAS	639089-54-6
Formula	C23H28N8OS
MW	464.59
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with K_i_app of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy.

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CL2144

Tozasertib(VX-680;MK-0457)

639089-54-6 98+%